ABSTRACT
PURPOSE: The purpose of this study was to compare the effects of 21℃ CO₂ and 37℃ CO₂ pneumoperitoneum on body temperature, blood pressure, heart rate, and acid-base balance. METHODS: Data were collected at a 1300-bed university hospital in Incheon, from February through September 2012. A total of 74 patients who underwent laparoscopic colectomy under general anesthesia with desflurane were randomly allocated to either a control group or an experimental group. The control group received 21℃ CO₂ pneumoperitoneum; the experimental group received 37℃ CO₂ pneumoperitoneum. The pneumoperitoneum of the two groups was under abdominal pressure 15 mmHg. Body temperature, systolic blood pressure, heart rate and acid-base balance were assessed at 30 minutes and 90 minutes after pneumoperitoneum, and again at 30 minutes after arriving at the Post Anesthesia Care Unit. RESULTS: Body temperature in the 37℃ CO2 pneumoperitoneum group was significantly higher (F=9.43, p<.001) compared to the 21℃ CO₂ group. However, there were no statistically significant differences in systolic blood pressure (p=.895), heart rate (p=.340), pH (p=.231), PaCO₂ (p=.490) and HCO3- (p=.768) between the two groups. CONCLUSION: Pneumoperitoneum of 37℃ CO₂ is effective for the increase of body temperature compared to pneumoperitonium of 21℃ CO₂, and it does not result in a decrease of blood pressure, heart rate or acid-base imbalance.
Subject(s)
Humans , Acid-Base Equilibrium , Acid-Base Imbalance , Anesthesia , Anesthesia, General , Blood Pressure , Body Temperature Changes , Body Temperature , Carbon Dioxide , Carbon , Colectomy , Heart Rate , Heart , Hemodynamics , Hydrogen-Ion Concentration , Laparoscopy , PneumoperitoneumABSTRACT
Whereas increasing concerns about radiation exposure to nuclear disasters or side effects of anticancer radiotherapy, relatively little research for radiation damages or remedy has been done. The purpose of this study was to establish level of LD70/30 (a lethal dose for 70% of mice within 30 days) by total-body γ irradiation (TBI) in a mouse model. For this purpose, at first, 8-week-old male ICR and C57BL/6N mice from A and B companies were received high dose (10, 11, 12 Gy) TBI. After irradiation, the body weight and survival rate were monitored for 30 days consecutively. In next experiment, 5-week-old male ICR and C57BL/6N mice from B company were received same dose irradiation. Results showed that survival rate and body weight change rate in inbred C57BL/6N mice were similar between A and B company. In ICR mice, however, survival rate and body weight change rate were completely different among the companies. Significant difference of survival rate both ICR and C57BL6N mice was not observed in between 5-week-old and 8-week-old groups receiving 10 or 12 Gy TBI. Our results indicate that the strain and age of mice, and even purchasing company (especially outbred), should be matched over experimental groups in TBI experiment. Based on our results, 8-week-old male ICR mice from B company subjected to 12 Gy of TBI showed LD70/30 and suitable as a mouse model for further development of new drug using the ideal total-body irradiation model.
Subject(s)
Animals , Humans , Male , Mice , Body Weight , Body Weight Changes , Disasters , Mice, Inbred ICR , Radiation Exposure , Radiotherapy , Survival RateABSTRACT
Most ingested foreign bodies spontaneously pass through the upper and lower intestinal tract. The impaction of an ingested foreign body in the colon is rare. Foreign bodies swallowed inadvertently often cause serious complications, such as perforation, obstruction, abscess formation, enterocolic fistula, or hemorrhage. Physicians should proceed with routine medical care while considering the possibility of the ingestion of a foreign body In cases where abdominal pain of an unknown origin is observed, particularly in elderly patients who wear dentures, alcoholics, mentally disturbed, or rapid eating, and presenting with altered bowel habits. We report a case of a colonoscopically-removed wooden toothpick that impacted the sigmoid colon and was complicated by the formation of a local abscess with a review of the literature.
Subject(s)
Aged , Humans , Abdominal Pain , Abscess , Alcoholics , Colon , Colon, Sigmoid , Colonoscopy , Dentures , Eating , Fistula , Foreign Bodies , HemorrhageABSTRACT
Hypereosinophilic syndrome, the disease with continuous over production of eosinophil from bone marrow without any identifiable underlying disorder, causes various symptoms or signs by infiltrating organs. As many as 28,780/mm3 eosinophils in peripheral blood, the eosinophilic hyperplasia in bone marrow and features of hepatic involvement -revealed elevated serum AST, ALT and ultrasonogram of abdomen showed the multiple nodules scattered throughout the liver, we have reached to make a diagnosis of the rare hyper eosinophilic syndrome carrying the eosinophil-rich exudate in pleural effusion. The patient showed improvement of clinical symptoms with oral administration of predinisolone, and we report this case with literature consideration.
Subject(s)
Humans , Abdomen , Administration, Oral , Bone Marrow , Diagnosis , Eosinophils , Exudates and Transudates , Hypereosinophilic Syndrome , Hyperplasia , Liver , Pleural Effusion , UltrasonographyABSTRACT
BACKGROUND/AIMS: Oral sodium phosphate has been shown to be effective and safe but causes intravascular volume contraction, changes in serum calcium and phopshate level, and sleep disturbance when given two doses every 12 hours. Because the evening dose is inconvenient for many patients, we gave single morning dose, and compared it with conventional 12-hour-split dose. METHODS: Sixty one patients drank 90 mL of sodium phosphate at 7:00 AM and 58 patients drank 45 mL of sodium phosphate at 7:00 PM and 7:00 AM respectively. RESULTS: There was no statistical difference in bowel cleansing between two groups (p=0.871). There was no significant difference in patient's tolerance and symptoms between two groups except sleep deprivation which was more frequent in the split dose group. None of the patients complained of postural dizziness or presyncope in both groups. Serum phosphate levels were increased and serum calcium levels were decreased after preparation in both groups, but patients showed no significant clinical symptoms such as tetany. CONCLUSION: This study suggests that giving a single morning dose of sodium phosphate is effective, well tolerated and safe in most patients for precolonoscopic cleansing, compared to conventional split dose of 12-hour interval.